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ATC N06AA21 · Non-Selective Monoamine Reuptake Inhibitors · updated 2 Nov 2026

Maprotiline shortage

As of 2 Nov 2026, Maprotiline has a reported shortage in 2 of the 16 countries we track (France, Japan), covering 5 products from 2 companies.

Is there a Maprotiline shortage?

Yes. As of 2 Nov 2026, Maprotiline is reported short in 2 of the 16 countries we track: France, Japan. The earliest expected return is 1 Feb 2027 (Japan). 3 of 5 affected products have no return date.

Countries2/16
Products5packs or presentations
Companies21 listed
Short since28 Mar 202519 months ago
Earliest return1 Feb 2027company estimate
Main reasonActive ingredient shortage
United StatesNo reported shortageCanadaNo reported shortageGermanyNo reported shortageFrance1 product shortItalyNo reported shortageSpainNo reported shortageIrelandNo reported shortageAustriaNo reported shortageBelgiumNo reported shortageSwitzerlandNo reported shortageCzechiaNo reported shortageNorwayNo reported shortageSwedenNo reported shortageJapan4 products shortNew ZealandNo reported shortageAustraliaNo reported shortage

Timeline

FranceJapan
20262027Ludiomil 25 et 75 mg, comprimé pelliculéLudiomil 25 et 75 mg, comprimé pelliculéマプロチリン塩酸塩錠10mg「アメル」マプロチリン塩酸塩錠10mg「アメル」マプロチリン塩酸塩錠25mg「アメル」マプロチリン塩酸塩錠25mg「アメル」ルジオミール錠10mgルジオミール錠10mgルジオミール錠25mgルジオミール錠25mgtoday

Solid bars run from the reported start to today; faded bars show the time left until the expected return. An arrow means no return date was given.

Which companies are short

products short, all countries
Kyowa Pharmaceutical2Sun Pharma2 SUNPHARMA

Listed: Sun Pharma SUNPHARMA · NSE

Compared with similar medicines

ATC group N06AA · Non-Selective Monoamine Reuptake Inhibitors
Amitriptyline5/16Imipramine5/16Clomipramine2/16Doxepin2/16Maprotiline2/16Nortriptyline2/16Trimipramine2/16Lofepramine1/16

Affected products

CountryProductCompanySinceExpected backReason
FRLudiomil 25 et 75 mg, comprimé pelliculé28 Mar 2025not givenNot stated
マプロチリン塩酸塩錠10mg「アメル」Kyowa Pharmaceutical1 Jun 20261 Feb 2027Active ingredient shortage
Raw material (active ingredient) supply problem
マプロチリン塩酸塩錠25mg「アメル」Kyowa Pharmaceutical1 Jun 20261 Feb 2027Active ingredient shortage
Raw material (active ingredient) supply problem
ルジオミール錠10mg limitedSun Pharma2 Jun 2026not givenIncreased demand
ルジオミール錠25mg limitedSun Pharma2 Jun 2026not givenIncreased demand

"Expected back" is the date the company gave the authority, when it gave one. Ask a pharmacist about alternatives.

Questions

Is there a Maprotiline shortage?

Yes. As of 2 Nov 2026, Maprotiline is reported short in 2 of the 16 countries we track: France, Japan. The earliest expected return is 1 Feb 2027 (Japan). 3 of 5 affected products have no return date.

When will Maprotiline be back in stock?

Companies expect supply back from 1 Feb 2027 in Japan; France: no date given; Japan: 1 Feb 2027. These are company estimates reported to each authority.

Why is Maprotiline in short supply?

The most common reason reported is: active ingredient shortage. Reasons by product are listed in the table below.

Which companies have Maprotiline shortages?

Kyowa Pharmaceutical, Sun Pharma.