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JP ATC L04AX03 · updated 2 Nov 2026
Methotrexate shortage in Japan
Is there a Methotrexate shortage in Japan?
Yes. As of 2 Nov 2026, 5 Methotrexate products are reported short in Japan, the first since 1 Aug 2021. No return date has been given. Main reason: manufacturing problem.
Also short in Canada, Germany, Italy, Czechia, Sweden. All countries.
Affected products in Japan
| Country | Product | Company | Since | Expected back | Reason |
|---|---|---|---|---|---|
| JP | メトトレキサートカプセル2mg「サンド」 | Sandoz | 1 Aug 2021 | not given | Active ingredient shortage Raw material (active ingredient) supply problem |
| JP | メトトレキサート錠2mg「日本臓器」 | 日本臓器製薬 | 30 Apr 2026 | not given | Manufacturing problem |
| JP | 注射用メソトレキセート50mg limited | Pfizer | 4 Sep 2026 | not given | Other |
| JP | 注射用メソトレキセート5mg limited | Pfizer | 4 Sep 2026 | not given | Other |
| JP | メトトレキサート錠2mg「トーワ」 limited | Towa (Pensa) | 22 Oct 2026 | not given | Manufacturing problem |
Source
MHLW (Ministry of Health, Labour and Welfare), supply status of prescription medicines. Official list. Prescription products under limited shipment or supply suspension (delistings excluded); one row per product.