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ATC L04AX03 · Other Immunosuppressants · updated 4 Nov 2026

Methotrexate shortage

As of 4 Nov 2026, Methotrexate has a reported shortage in 6 of the 16 countries we track (Canada, Germany, Italy, Czechia, Sweden, Japan), covering 20 products from 9 companies.

Is there a Methotrexate shortage?

Yes. As of 4 Nov 2026, Methotrexate is reported short in 6 of the 16 countries we track: Canada, Germany, Italy, Czechia, Sweden, Japan. The earliest expected return is 15 Nov 2026 (Sweden). 12 of 20 affected products have no return date. New since 5 Oct 2026: Sweden, Japan.

Countries6/16
Products20packs or presentations
Companies93 listed
Short since1 Aug 20215.3 years ago
Earliest return15 Nov 2026company estimate
Main reasonManufacturing problem
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United StatesNo reported shortageCanada5 products shortGermany1 product shortFranceNo reported shortageItaly2 products shortSpainNo reported shortageIrelandNo reported shortageAustriaNo reported shortageBelgiumNo reported shortageSwitzerlandNo reported shortageCzechia5 products shortNorwayNo reported shortageSweden2 products shortJapan5 products shortNew ZealandNo reported shortageAustraliaNo reported shortage

spreading How the shortage spread

All cross-border shortages

Countries in the order the shortage started there (earliest start date of a product still short). First reported in Japan on 1 Aug 2021; most recently in Sweden on 29 Oct 2026.

Not on the official list in: United States, France, Spain, Ireland, Austria, Belgium, Switzerland, Norway, New Zealand, Australia.

Timeline

CanadaGermanyItalyCzechiaSwedenJapan
20222023202420252026NORDIMET (1 pre-filled auto-injector pen)NORDIMET (1 pre-filled auto-injector pen)NORDIMET (1 pre-filled auto-injector pen)NORDIMET (1 pre-filled auto-injector pen)NORDIMET (1 pre-filled auto-injector pen)NORDIMET (1 pre-filled auto-injector pen)NORDIMET (1 pre-filled auto-injector pen)NORDIMET (1 pre-filled auto-injector pen)NORDIMET (1 pre-filled auto-injector pen)NORDIMET (1 pre-filled auto-injector pen)Methofill 50 mg/ml Injektionslösung in einerMethofill 50 mg/ml Injektionslösung in einer FertigspritzeMETOTREXATO DOC GENERICIMETOTREXATO DOC GENERICIVELOSVELOSFOXIEMO 10MG 10MG INJ SOL ISP 1X0,267ML+J+TFOXIEMO 10MG 10MG INJ SOL ISP 1X0,267ML+J+TFOXIEMO 15MG 15MG INJ SOL ISP 1X0,4ML+J+TFOXIEMO 15MG 15MG INJ SOL ISP 1X0,4ML+J+TFOXIEMO 20MG 20MG INJ SOL ISP 1X0,533+J+TFOXIEMO 20MG 20MG INJ SOL ISP 1X0,533+J+TFOXIEMO 25MG 25MG INJ SOL ISP 1X0,667ML+J+TFOXIEMO 25MG 25MG INJ SOL ISP 1X0,667ML+J+TFOXIEMO 7,5MG 7,5MG INJ SOL ISP 1X0,2ML+J+TFOXIEMO 7,5MG 7,5MG INJ SOL ISP 1X0,2ML+J+TInjexate 10 mg Förfylld injektor, 4 x 1 st (Injexate 10 mg Förfylld injektor, 4 x 1 st (0,20 ml)Injexate 17,5 mg Förfylld injektor, 4 x 1 stInjexate 17,5 mg Förfylld injektor, 4 x 1 st (0,35 ml)メトトレキサートカプセル2mg「サンド」メトトレキサートカプセル2mg「サンド」メトトレキサート錠2mg「日本臓器」メトトレキサート錠2mg「日本臓器」注射用メソトレキセート50mg注射用メソトレキセート50mg注射用メソトレキセート5mg注射用メソトレキセート5mgメトトレキサート錠2mg「トーワ」メトトレキサート錠2mg「トーワ」today

Solid bars run from the reported start to today; faded bars show the time left until the expected return. An arrow means no return date was given.

Which companies are short

products short, all countries
Nordic Group5Easymed S.R.O.5Accord (Intas)3Pfizer2 PFEDoc Generici1Difa Cooper1Sandoz1 SDZ日本臓器製薬1Towa (Pensa)1 4553

Listed: Sandoz SDZ · SIX Swiss, Pfizer PFE · NYSE, Towa (Pensa) 4553 · Tokyo

Compared with similar medicines

ATC group L04AX · Other Immunosuppressants
Lenalidomide10/16Methotrexate6/16Pirfenidone6/16Pomalidomide6/16Dimethyl Fumarate5/16Azathioprine3/16

Affected products

CountryProductCompanySinceExpected backReason
CANORDIMET (1 pre-filled auto-injector pen)NORDIC GROUP B.V.2 Jun 2025not givenOther
Other (Please describe in comments)
CANORDIMET (1 pre-filled auto-injector pen)NORDIC GROUP B.V.31 Mar 2026not givenOther
Other (Please describe in comments)
CANORDIMET (1 pre-filled auto-injector pen)NORDIC GROUP B.V.31 Mar 2026not givenOther
Other (Please describe in comments)
CANORDIMET (1 pre-filled auto-injector pen)NORDIC GROUP B.V.31 Mar 2026not givenOther
Other (Please describe in comments)
CANORDIMET (1 pre-filled auto-injector pen)NORDIC GROUP B.V.31 Mar 2026not givenOther
Other (Please describe in comments)
DEMethofill 50 mg/ml Injektionslösung in einer FertigspritzeAccord Healthcare B.V.29 Jul 202631 Dec 2026Manufacturing problem
Probleme in der Herstellung
ITMETOTREXATO DOC GENERICIDOC GENERICI SRL31 Aug 2026not givenManufacturing problem
Problemi produttivi
ITVELOSDIFA COOPER S.P.A.10 Sep 2026not givenIncreased demand
Elevata richiesta/problemi produttivi
CZFOXIEMO 10MG 10MG INJ SOL ISP 1X0,267ML+J+TeasyMed s.r.o., Praha 103 Feb 202525 Mar 2027Manufacturing problem
Výrobní důvody
CZFOXIEMO 15MG 15MG INJ SOL ISP 1X0,4ML+J+TeasyMed s.r.o., Praha 103 Feb 202525 Mar 2027Manufacturing problem
Výrobní důvody
CZFOXIEMO 20MG 20MG INJ SOL ISP 1X0,533+J+TeasyMed s.r.o., Praha 103 Feb 202525 Mar 2027Manufacturing problem
Výrobní důvody
CZFOXIEMO 25MG 25MG INJ SOL ISP 1X0,667ML+J+TeasyMed s.r.o., Praha 103 Feb 202525 Mar 2027Manufacturing problem
Výrobní důvody
CZFOXIEMO 7,5MG 7,5MG INJ SOL ISP 1X0,2ML+J+TeasyMed s.r.o., Praha 103 Feb 202525 Mar 2027Manufacturing problem
Výrobní důvody
SEInjexate 10 mg Förfylld injektor, 4 x 1 st (0,20 ml)Accord Healthcare B.V.29 Oct 202615 Nov 2026Not stated
SEInjexate 17,5 mg Förfylld injektor, 4 x 1 st (0,35 ml)Accord Healthcare B.V.29 Oct 20261 Feb 2027Not stated
メトトレキサートカプセル2mg「サンド」Sandoz1 Aug 2021not givenActive ingredient shortage
Raw material (active ingredient) supply problem
メトトレキサート錠2mg「日本臓器」日本臓器製薬30 Apr 2026not givenManufacturing problem
注射用メソトレキセート50mg limitedPfizer4 Sep 2026not givenOther
注射用メソトレキセート5mg limitedPfizer4 Sep 2026not givenOther
メトトレキサート錠2mg「トーワ」 limitedTowa (Pensa)22 Oct 2026not givenManufacturing problem

"Expected back" is the date the company gave the authority, when it gave one. Ask a pharmacist about alternatives.

Questions

Is there a Methotrexate shortage?

Yes. As of 4 Nov 2026, Methotrexate is reported short in 6 of the 16 countries we track: Canada, Germany, Italy, Czechia, Sweden, Japan. The earliest expected return is 15 Nov 2026 (Sweden). 12 of 20 affected products have no return date. New since 5 Oct 2026: Sweden, Japan.

When will Methotrexate be back in stock?

Companies expect supply back from 15 Nov 2026 in Sweden; Canada: no date given; Germany: 31 Dec 2026; Italy: no date given; Czechia: 25 Mar 2027; Sweden: 15 Nov 2026; Japan: no date given. These are company estimates reported to each authority.

Why is Methotrexate in short supply?

The most common reason reported is: manufacturing problem. Reasons by product are listed in the table below.

Which companies have Methotrexate shortages?

Nordic Group, Easymed S.R.O., Accord (Intas), Pfizer, Doc Generici, Difa Cooper, Sandoz, 日本臓器製薬, Towa (Pensa).