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ATC V03AF04 · Detoxifying Agents for Antineoplastic Treatment · updated 2 Nov 2026

Calcium Levofolinate shortage

As of 2 Nov 2026, Calcium Levofolinate has a reported shortage in 2 of the 16 countries we track (France, Japan), covering 4 products from 3 companies.

Is there a Calcium Levofolinate shortage?

Yes. As of 2 Nov 2026, Calcium Levofolinate is reported short in 2 of the 16 countries we track: France, Japan. No company has given a return date. New since 3 Oct 2026: Japan.

Countries2/16
Products4packs or presentations
Companies32 listed
Short since17 Jan 202522 months ago
Earliest returnnot givencompany estimate
Main reasonIncreased demand
United StatesNo reported shortageCanadaNo reported shortageGermanyNo reported shortageFrance1 product shortItalyNo reported shortageSpainNo reported shortageIrelandNo reported shortageAustriaNo reported shortageBelgiumNo reported shortageSwitzerlandNo reported shortageCzechiaNo reported shortageNorwayNo reported shortageSwedenNo reported shortageJapan3 products shortNew ZealandNo reported shortageAustraliaNo reported shortage

Timeline

FranceJapan
20262027Lévofolinate de calcium Zentiva 10 mg/ml et Lévofolinate de calcium Zentiva 10 mg/ml et 25 mg/2,5 ml, solution injectable (IM/IV)レボホリナート点滴静注用100mg「NP」レボホリナート点滴静注用100mg「NP」レボホリナート点滴静注用100mg「トーワ」レボホリナート点滴静注用100mg「トーワ」レボホリナート点滴静注用25mg「トーワ」レボホリナート点滴静注用25mg「トーワ」today

Solid bars run from the reported start to today; faded bars show the time left until the expected return. An arrow means no return date was given.

Which companies are short

products short, all countries
Towa (Pensa)2 4553Zentiva1Nipro1 8086

Listed: Nipro 8086 · Tokyo, Towa (Pensa) 4553 · Tokyo

Compared with similar medicines

ATC group V03AF · Detoxifying Agents for Antineoplastic Treatment
Calcium Folinate7/16Mesna3/16Calcium Levofolinate2/16Dexrazoxane1/16

Affected products

CountryProductCompanySinceExpected backReason
FRLévofolinate de calcium Zentiva 10 mg/ml et 25 mg/2,5 ml, solution injectable (IM/IV) limitedZentiva23 Jul 2026not givenNot stated
レボホリナート点滴静注用100mg「NP」 limitedNipro17 Jan 2025not givenOther
レボホリナート点滴静注用100mg「トーワ」 limitedTowa (Pensa)29 Oct 2026not givenIncreased demand
レボホリナート点滴静注用25mg「トーワ」 limitedTowa (Pensa)29 Oct 2026not givenIncreased demand

"Expected back" is the date the company gave the authority, when it gave one. Ask a pharmacist about alternatives.

Questions

Is there a Calcium Levofolinate shortage?

Yes. As of 2 Nov 2026, Calcium Levofolinate is reported short in 2 of the 16 countries we track: France, Japan. No company has given a return date. New since 3 Oct 2026: Japan.

When will Calcium Levofolinate be back in stock?

No return date has been given; France: no date given; Japan: no date given. These are company estimates reported to each authority.

Why is Calcium Levofolinate in short supply?

The most common reason reported is: increased demand. Reasons by product are listed in the table below.

Which companies have Calcium Levofolinate shortages?

Towa (Pensa), Zentiva, Nipro.